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Its a two-way street in IBD, with the gut microbiome changes potentially causing high homocysteine, but then high homocysteine will increase the inflammation in the gut.[ref] Gastrointestinal production of homocysteine: Gut microbes that produce folate: The amount of folate produced by the gut microbiome is on a similar scale to what we get from food, so it is a significant source of folate for most people

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Databases such as PubMed, Scopus, and Web of Science were utilized, employing relevant keywords related to the ME/CFS, Gut-Brain Axis, Gut Health, Intestinal Dysbiosis, Microbiome Dysbiosis, Pathophysiology, and Therapeutic Approaches. The goal was to extract qualitative and quantitative data from studies that investigate gut microbiota composition, assess inflammatory markers, and evaluate the therapeutic outcomes of interventions targeting the microbiome